Tube of Beta-Amyloid (1-42) peptide, HL488-labeled
Peptides

Beta-Amyloid (1-42), HiLyte™ Fluor 488-labeled - 0.1 mg

€229.00
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  • Cat.Number : AS-60479-01
  • Availability :
    In stock

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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. This is a fluorescent (HiLyte™ Fluor 488)-labeled ß-Amyloid peptide, Abs/Em=503/528 nm. Hilyte™ Fluor 488 labeled Aß (1-42) has a brighter intensity than FAM-labeled Aß (1-42).

Specifications

Chemistry
Sequence one letter code
  • HiLyte Fluor™ 488-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • Hilyte™ Fluor488-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Molecular Mass/ Weight
  • 4870.5
Properties
Absorbance (nm)
  • 503
Emission (nm)
  • 528
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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  • S. Hickman
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LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model

Neurobiol Dis. . 2008 Apr 01 ; 30(1) 94 | DOI : 10.1016/j.nbd.2007.12.005

  • B. Nazer
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Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation

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  • et al

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

Biochemistry. . 2014 Apr 09 ; 53(15) 2442 | DOI : 10.1021/bi401606f

  • P. Narayan
  • et al

Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ (1–40) and Aβ (1–42) Aggregation.

Chem Biol . 2014 Jun 19 ; 21(6) 732 | DOI : 10.1016/j.chembiol.2014.03.014

  • EK. Esbjörner