We offer flexibility and assistance
at any step of the project

 

 

Animal studies

Tests

  • Residues testing
  • Tolerance
  • Bio-equivalence
  • Efficacy
  • Appetence
  • Acute and chronical toxicit
  • Sensitization
  • Pharmacokinetics
  • And others…

Species

  • Bovine
  • Broiler
  • Cat
  • Chicken
  • Dog
  • Sheep
  • Goat
  • Horse
  • Mouse
  • Pheasant
  • Pig
  • Rabbit
  • Rat
  • Turkey
  • And other …

Routes of administration

It will depend on the target species, test item and test system:

  • Per os
  • Intradermal
  • Intramuscular
  • Intra-vaginal
  • Intra-mammary
  • Intra-uterine
  • Intra-venous
  • Intra-ocular
  • Intra-nasal
  • Topical
  • Sub-cutaneous

Analytical and clinical chemistry testing

It concentrate on method validation and measurement of test items and their metabolites in foodstuffs of animal origin (tissues, plasma, milk, eggs, excrements).

Why working with us?

High quality service

Our dedicated veterinary department provides a wide range of in vivo but also analytical testing services that are carried out with respect to the OECD and the EU principles of Good Laboratory Practices

 

Tailored offer

We develop and conduct customized studies to ensure that the safety and efficacy assessments fit with your test item.

We test various items

We can evaluate pharmaceutical, biopharmaceutical, veterinary, chemical and agrochemical test items.

 

Advanced equipment

Our facilities are equipped with high performance LC/MS-MS, multiple chromatography systems, small-animal imaging (X-Ray micro-CT microtomography, in vivo bioluminescence imaging).

Study adaptation

We can adapt study designs to meet our customer’s specific needs.

These specialty designs include among others microsurgery, immunotherapy studies in humanized animal models, disease models development and evaluations, coagulation studies, stem cell therapy, vaccine efficacy and safety, biologicals pharmacokinetics...

State-of-the-art infrastructure

Our infrastructures meet the highest standards

  • Hygiene (Specified Pathogen Free animals)
  • Ethics (in-house ethical committee)
  • Animal welfare (2010-63-UE Directive, FELASA…)
  • Biosafety (ventilated cages; BL2 –BL3 facilities)

Animal models

Overview

Are you conducting pre-clinical activities using animal models?

We work with mouse, rat and rabbit models (spontaneous, induced, transgenic).

Here are some example of models:

  • Non-alcoholic steatohepatitis (NASH) models (mouse)
  • Fibrosis Model (rat)
  • ACLF (Acute-on-Chronic Liver Failure) Model (rat)

We have a strong expertise in specialized area and assist our customers in their specific research projects related to the following fields:

  • Immunology
  • Cancerology
  • Cell therapy
  • Infectiology
  • Autoimmune and chronic diseases

Catheter-induced clothing (rabbit)

  • B16 – Mouse Melanoma
  • 4T1 – Mouse Mammary Carcinoma
  • PancO2 – Mouse Pancreatic Adenocarcinoma
  • CT26 – Mouse Colorectal Carcinoma
  • GL261Lv – Mouse Glioblastoma
  • HCT116 – Human Colorectal Carcinoma
  • Colo205 – Human Colorectal Carcinoma
  • PDX – Human Hepatocellular Carcinoma
Microsurgery
  • Intra-splenic injection (mouse, rat)
  • Intra-hepatic injection (mouse, rat, rabbit)
  • Intra-portal injection (mouse, rat)
  • Intra-mammary injection (mouse)
  • Catheterization of bile duct (rat)
  • Partial hepatectomy (mouse)
  • Injection under the capsular kidney (rat)
  • Renal Ischemia Reperfusion Injury (IRI model in mouse)
Musculo-skeletal surgery
  • Knee and joint surgery (rabbit and mouse)
  • Partial meniscectomy (rat)
  • Osteoarthritis Rabbit Model after Transection of the Right Anterior Cruciate Ligament (ACLT model)
  • Rheumatoid arthritis rat models: Collagen induced arthritis (CIA) and Streptococcal cell walls (SCW)
Bone surgery
  • Centro-medullar implant into the knee (rat)
  • Osseous defects (rat)

Our Methods & Equipments

They include the last generation, high performance imaging systems (IVIS, µCT-Scan), and multiple technologies such as:

Molecular biology

  • ImmunoAssays incuding IHC analyses
  • PCR

Cell-based Assays

  • Toxicity
  • Functionality
  • ActivityPotency

Mass Spectrometry

  • Qualitative analysis
  • Quantitative analysis
  • Small compounds
  • Peptides
  • Proteins

Cytometry services

  • Cell sorting: enrichment, purification and cloning of different populations
  • Multiparametric analysis for phenotyping: various types of cells
  • Intracellular cytokine secretion: CBA or immunostaining
  • Cell proliferation: Ag-specific proliferation, CFSE, BrdU, KI67, …
  • Cell cycle: G1 –S –G2 –M relative content
  • Cell viability: PI (necrosis) and AnnexinV (apoptosis) cells
  • MHC Dextramer™ technology
  • Fluorescent proteins
  • Multiplex Immunoassay on microbeads